diff --git a/sycl/unittests/kernel-and-program/MultipleDevsCache.cpp b/sycl/unittests/kernel-and-program/MultipleDevsCache.cpp
index 61f2315d156b3..d1d2dd3cc9db4 100644
--- a/sycl/unittests/kernel-and-program/MultipleDevsCache.cpp
+++ b/sycl/unittests/kernel-and-program/MultipleDevsCache.cpp
@@ -107,12 +107,7 @@ class MultipleDeviceCacheTest
 
 // Test that program is retained for each subset of the list of devices and that
 // number of urKernelRelease calls is correct.
-#ifdef _WIN32
-// https://github.com/intel/llvm/issues/21553
-TEST_P(MultipleDeviceCacheTest, DISABLED_ProgramRetain) {
-#else
 TEST_P(MultipleDeviceCacheTest, ProgramRetain) {
-#endif
   {
     // Reset counters
     RetainCounter = 0;