Issues

• Produce multiple different optimized results

  Edinburgh-Genome-Foundry/DnaChisel#114 · Filter by author SZ-qing opened on Jun 3, 2026
  1

• Low Codon Adaptation Index on optimized sequence

  Edinburgh-Genome-Foundry/DnaChisel#113 · Filter by author derek2652-star opened on May 5, 2026
  1

• Unexpected Mutation of codon_usage_table Dictionary During Optimization

  Edinburgh-Genome-Foundry/DnaChisel#111 · Filter by author wangjiawen2013 opened on Apr 27, 2026
  1

  

• Minimize CG

  Edinburgh-Genome-Foundry/DnaChisel#110 · Filter by author wangjiawen2013 opened on Apr 23, 2026
  2

• Support for Uridine Depletion (UD) optimization objectives

  Edinburgh-Genome-Foundry/DnaChisel#107 · Filter by author wangjiawen2013 opened on Apr 17, 2026
  5

• Include / point to "CONTRIBUTING" in the documentation (readme)

  Task

  Edinburgh-Genome-Foundry/DnaChisel#105 · Filter by author veghp opened on Feb 4, 2026
  

• Feature: PDF report generation optional during optimize_with_report

  enhancement
  Edinburgh-Genome-Foundry/DnaChisel#102 · Filter by author lifefoundry-scott opened on Jul 11, 2025
  2

  

• Question: how to get under-optimal sequences during optimization?

  Edinburgh-Genome-Foundry/DnaChisel#100 · Filter by author wyattxuanyang opened on May 1, 2025
  2

• Code to calculate codon usage tables

  Edinburgh-Genome-Foundry/DnaChisel#98 · Filter by author ewallace opened on Feb 17, 2025

• Consequences of partial CDS optimization

  Edinburgh-Genome-Foundry/DnaChisel#96 · Filter by author i-hate-this-username opened on Feb 12, 2025
  1

• Question: No boost for AllowPrimer

  Edinburgh-Genome-Foundry/DnaChisel#71 · Filter by author jlerman44 opened on Feb 7, 2023
  1

• Request: use updated codon usage tables

  Edinburgh-Genome-Foundry/DnaChisel#62 · Filter by author eggrandio opened on Sep 7, 2021
  13

  

• Feature: Add "use_breach_form" field in "constraints_breaches_dataframe"

  Edinburgh-Genome-Foundry/DnaChisel#56 · Filter by author avemeva opened on Apr 9, 2021
  3

• Feature: Add GC content variance constraint

  enhancement
  Edinburgh-Genome-Foundry/DnaChisel#54 · Filter by author avemeva opened on Apr 8, 2021
  8

  

• Sequence diversity in output from CodonOptimize

  Edinburgh-Genome-Foundry/DnaChisel#39 · Filter by author jlerman44 opened on Jul 6, 2020
  3

• Suggestion: rename biotools to tools

  Edinburgh-Genome-Foundry/DnaChisel#33 · Filter by author Lix1993 opened on Dec 31, 2019
  1

• suggestion: put builtin_specification to Specification folder and split it into sub folders by specification type

  Edinburgh-Genome-Foundry/DnaChisel#28 · Filter by author Lix1993 opened on Dec 16, 2019
  3

• can I generate a sequence with a sequence with 'medium' score?

  Edinburgh-Genome-Foundry/DnaChisel#27 · Filter by author Lix1993 opened on Dec 5, 2019
  3

• Support for optimization of RNA structure

  Edinburgh-Genome-Foundry/DnaChisel#12 · Filter by author simone-pignotti opened on Jul 17, 2019
  3