I am a neuroscientist investigating neurodegeneration, neuroinflammation, and neuromuscular diseases through molecular biology, cellular biology, transcriptomics, bioinformatics, and quantitative imaging.
I am also developing computational space biology as a complementary research area. I am a member of the Brain Analysis Working Group within NASA’s Open Science Data Repository (OSDR) initiative, where I contribute to an international scientific community dedicated to advancing collaborative, open-science research using space biology datasets.
My work focuses on building and applying computational workflows that help make complex biological datasets interpretable and reproducible.
I am committed to open science, transparent methods, and reusable research software.
- Neurodegeneration and neuromuscular biology — ALS/MND, skeletal muscle, motor neurons, and neuromuscular junctions
- RNA and molecular data analysis — RNA-seq, microRNA biology, alternative polyadenylation, and transcriptomic profiling
- Computational space biology — spaceflight biology, unloading/reloading models, and spaceflight omics analysis
- Quantitative imaging and image analysis — confocal microscopy, fluorescence localisation, morphometry and spatial analysis
- Data science for biology — reproducible analysis pipelines, statistical modelling, visualisation, and open computational workflows
| Repository | Focus |
|---|---|
| ALS × spaceflight muscle transcriptomics | Comparative transcriptomics, pathway enrichment, and reversible gene-programme analysis |
| NMJ-MN-image-analysis-toolkit | Morphometric and localisation analysis of neuromuscular-junction and motor-neuron microscopy images |
| interneuron-microscopy-analysis | ImageJ/Fiji and MATLAB pipeline for interneuron quantification and spatial-distribution analysis |
| long-read-RNA-seq-plotting-suite | Utilities for inspecting, extracting and visualising long-read RNA-seq data |
| qPCR-replicate-analysis | Statistical analysis of qPCR technical replicates and reproducibility |
| cell-morphometry | Quantitative extraction of cell-shape and morphology descriptors from microscopy images |
| colocalisation | Pixel-based fluorescence colocalisation analysis for confocal microscopy images |
These analysis repositories are currently being prepared for public release.
| Project | Status |
|---|---|
| Alternative polyadenylation in ALS muscle | APA, mRNA expression, and regulatory analysis across disease stages · Repository coming soon |
| microRNA biomarkers in ALS plasma | Longitudinal biomarker analysis and cross-cohort comparison · Repository coming soon |
Languages and platforms
Methods
RNA-seq · Differential expression · DESeq2 · microRNA analysis · Alternative polyadenylation · Pathway enrichment · Confocal microscopy · Image analysis · Statistical analysis · Data visualisation · Open science
- Publications: All publications · ORCID · Google Scholar
- Open transcriptomics and other datasets: PRJEB96186 · PRJEB61796 · RSV × MND mortality
- Research background: Research experience · Coding experience