halfmarble is a strict "Glass Box" bioinformatics platform designed for the Parkinson's Disease (PD) community.
As a neurodegenerative data architecture, halfmarble is engineered to track deterministic Pharmacokinetic (PK) modeling against objective motor testing and continuous metabolic state.
In an era of dangerous algorithmic hallucinations in healthcare, halfmarble rejects the "black box." Every parameter, absorption curve, and metric traces directly to published, verifiable clinical science.
The software platform currently consists of functional web prototypes:
- SteadyDoseTracker: Deterministic Bateman absorption modeling for levodopa pharmacokinetics.
- SteadyFastingTracker: Metabolic window tracking aligned with neuro-compromised needs.
- SteadyFuelTracker: Engineered around Therapeutic Carbohydrate Restriction (TCR) guidance to log carbohydrate/protein timing and nutritional ketosis.
halfmarble also builds dedicated hardware:
- SteadyHandTool: Open-source (CERN-OHL-S-2.0) high-mass tremor-dampening fixture for fine-motor work.
- UnSteadyRing: Wearable kinematic and biometric sensor system — ten passive chipless fractal-resonant rings designed to be excited by low-power passive RF (reflected-wave telemetry) from two wrist-worn hubs that would also capture single-lead ECG, PPG, and skin temperature, plus an ankle hub for gait and freezing-of-gait. Seventeen provisional patent applications filed; sensing hardware is in early R&D (design stage).
Patient data is not a commodity. By default it never leaves your device; any future sharing is opt-in, IRB-approved, and aggregate-only (never individual-level records):
- On-device first — computation runs on your device; raw data is never required to leave it.
- Differential privacy under a single budgeted total privacy budget (ε), accounted across all releases — not a fresh budget per query — computed on-device or via federated analytics where possible. (Generalization/grouping is a step inside this mechanism, not a standalone guarantee.)
halfmarble is not a startup; it is a patient-led R&D fight. The science is the engine—we just built the dashboard.
To ensure the underlying science continues to advance, we legally pledge a flat percentage of our software net profits to the institutions driving the vanguard of research:
- 2.5% to Team Fox, the grassroots fundraising program of The Michael J. Fox Foundation
- 2.5% to the Public Health Collaboration (PHC)
For live prototypes and full clinical documentation, visit halfmarble.com.