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feat(pon): merge cohort PON with external PON before hotspot masking - #29
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Add optional gatk_resources.extra_panel_of_normals and rule pon_combine to sanitize contigs against the reference dictionary, drop records on absent contigs, and merge cohort + external PON VCFs (bcftools concat -a -D) prior to hotspot masking in pon_mask_hotspots. Closes #28
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Summary
gatk_resources.extra_panel_of_normalsto config, schema, and docs (README.md,config/README.md).pon_combinerule inworkflow/rules/mutect2.smkto align header contigs with the reference dictionary, drop records on contigs absent from the reference, and merge cohortpon.vcf.gzwithextra_panel_of_normals(bcftools concat -a -D) intopon.combined.vcf.gz.pon_mask_hotspotsandget_pon()inworkflow/rules/common.smkso combined PoNs are masked intopon.combined.masked.vcf.gz(orpon.combined.vcf.gzwhen unmasked), leaving prebuiltpanel_of_normalsbehaviour unchanged.Closes #28